No. 1 team in the nation (AP Poll, No. 2 in BCS), playing at home against a ranked divisional rival with two losses on its record and an elusive redshirt freshman quarterback directing its offense.
Last week it was top-ranked Alabama losing to No. 15 Texas A&M to shake up the national championship race.
This week, new No. 1 Oregon hosts No. 14 Stanford, looking to avoid a repeat.
The Tide's loss has left the Ducks, second in the BCS, and No. 2 Kansas State, first in the BCS, on course to play for the national championship.
The Wildcats have what looks like an easier task this week a game at Baylor (4-5).
No. 3 Notre Dame plays Wake Forest (5-5) on Saturday, hoping to stay unbeaten and take one of those spots if the Cardinal or Bears can pull an upset. No. 4 Alabama needs two upsets to get back into the front row.
The Ducks seem to be walking into a similar situation as the Tide last week. The Cardinal even have their own version of Johnny Football.
New starting quarterback Kevin Hogan has invigorated Stanford's offense, first in an easy victory against Colorado, and then in last week's huge win against Oregon State.
Hogan was 22 for 29 for 254 yards against the Beavers. He's not quite Johnny Manziel on the move, but he did run for 49 yards on 11 carries.
The Ducks have dominated the rivalry historically, but only recently with Stanford's rise to power has it become a huge game on the West Coast. A wild one, too.
Stanford beat the Ducks 51-42 in 2009. The last two seasons Oregon struck back with 52-31 and 53-30 victories in which the Ducks pulled away in the second half.
Oregon comes in with all sorts of injuries nagging its defense. The Ducks will likely be down to their third starting free safety, and they had five defensive linemen miss most or all of last week's game.
Stanford's defense led by linebackers Chase Thomas and Shayne Skov has been one of the best in the nation, ranking ninth in yards per play (4.48) and sacks (42).
"They're good against the run, they're good against the pass," Oregon Coach Chip Kelly said. "I think it's a huge challenge for us offensively getting matched up against what will be the best defense we've faced so far. Lot of veteran players on that side of the ball that play very hard."
But as the recent scores show, the Cardinal have yet to figure out a way slow Oregon's spread, which is operating better than ever behind another redshirt freshman quarterback, Marcus Mariota. The Ducks are the highest scoring team in the nation at 55 points per game, with at least 42 in every game.
Of course, Alabama hadn't allowed more than 17 point in a game before A&M came to town and put 29 on the Tide.
No. 14 Stanford (plus 20 1/2) at No. 1 Oregon
Ducks clinch Pac-12 north with victory ... OREGON 45-28.
No. 2 Kansas State (minus 11 1/2) at Baylor
Bears No. 2 in country on total offense, last in total defense ... KANSAS STATE 55-31.
Wake Forest (plus 23 1/2) at No. 3 Notre Dame
Irish finishing up ACC portion of the schedule ... NOTRE DAME 38-14.
Western Carolina (no line) at No. 4 Alabama
Biggest mismatch in this week's FCS-SEC challenge ... It could be ALABAMA 100-0 if Tide wanted it to be.
Georgia Southern (no line) at No. 5 Georgia
Eagles option often gives big boys headaches ... GEORGIA 48-24.
No. 6 Ohio State (plus 3) at Wisconsin
Buckeyes quest for perfection faces tough test ... WISCONSIN 28-24.
Jacksonville State (no line) at No. 7 Florida
Gators injured QB Jeff Driskel gets week off ... FLORIDA 42-10.
Mississippi (plus 18 1/2) at No. 8 LSU
Tigers hoping for BCS at-large bid, Rebels need win for bowl eligibility ... LSU 35-14.
Sam Houston State (no line) at No. 9 Texas A&M
Little more time for Aggies to bask ... TEXAS A&M 58-17.
No. 10 Florida State (minus 31) at Maryland
Seminoles can clinch ACC Atlantic Division ... 45-7.
North Carolina State (minus 17) at No. 11 Clemson
Tigers need Terps to pull upset to pass 'Noles ... CLEMSON 45-21.
Wofford (no line) at No. 12 South Carolina
Gamecocks tuneup for Tigers ... SOUTH CAROLINA 38-17.
No. 13 Oklahoma (minus 11) at West Virginia
Mountaineers have gone from top-five to trying to get bowl-eligible ... OKLAHOMA 48-24.
California (off) at No. 15 Oregon State
Both teams have QB injury problems ... OREGON STATE 28-13.
Minnesota (plus 19 1/2) at No. 16 Nebraska
Huskers win plus Michigan loss gives Nebraska division title ... NEBRASKA 45-17.
No. 21 Southern California (minus 4) at No. 17 UCLA
Winner clinches Pac-12 South ... USC 35-28.
Utah State (minus 3) at No. 19 Louisiana Tech
Spread tells all you need to know about under-appreciated Aggies ... LOUISIANA TECH 40-38.
No. 22 Rutgers (plus 6 1/2) at Cincinnati
Rutgers is in control of Big East race, for now ... CINCINNATI 21-16.
Iowa (off) at No. 23 Michigan
With or without Denard Robinson, Wolverines should be fine ... MICHIGAN 24-14.
No. 23 Texas Tech (plus 10 1/2) at Oklahoma State
Cowboys looking for fourth straight against Red Raiders ... OKLAHOMA ST. 38-31.
No. 25 Kent State (plus 2 1/2) at Bowling Green
Hard to stay ranked in tough MAC ... KENT STATE 34-28.
Last week's record: 19-2 (straight); 11-9 (vs. points)
Season record: 182-37 (straight); 105-95 (vs. points)
Best bets: 5-6.
Upset specials: 7-4.