Britney Spears begins her two-year residency at Planet Hollywood Resort & Casino on Friday, just in time to catch the town's massive New Year's Eve crowds.
The Grammy-winning singer will perform 50 shows each in 2014 and 2015. Casino executives say the gig may be extended if it proves a success.
Spears, 32, will recap her biggest hits, including "Oops. I Did It Again," ''...Baby One More Time" and "Toxic."
She will be singing along to a soundtrack of her own voice.
Kelly Frey, a spokeswoman for Planet Hollywood parent company Caesars Entertainment Corp., said the track is intended to help Spears through the more physically grueling sets.
A collection of pop stars, including Katy Perry and Miley Cyrus, are expected to attend the opening.
Spears is among the youngest stars to have settled down to quasi-retirement in Las Vegas. Other successful Strip headliners include Celine Dion and Elton John.
The show takes place in a relatively intimate theater with nightclub touches, including table and bottle service. Tickets range from $59 to $179.
Before the announcement of the residency, Spears' strongest Las Vegas tie derived from her short-lived marriage here. A 22-year-old Spears married her childhood friend in Sin City in 2004, and got the marriage annulled 55 hours later.
Spears made a grand Las Vegas entrance this month with fire-breathers, contortionists, snake charmers and hunky dancers welcoming her during a staged event at Planet Hollywood.
A portion of the Strip was temporarily closed so that she could pull up to the casino in a convertible. Spears told Las Vegas, "this is my city" now, then immediately went home to Los Angeles.
Spears has released seven platinum-plus albums since she debuted on the music scene in 1999. Her eighth album, "Britney Jean," was released this month to tepid reviews.